weight loss
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Dr Catriona Maybury
MRCP, PhD
Declan Lismore
Medical Director
Dr Paul Davis
MBChB, MRCP
Dr Safia Hussain
PhD
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Weight loss medications
Can I switch from Mounjaro to Wegovy?
Yes. With the recent price increase for Mounjaro, Wegovy has become the more cost-effective option for weight loss and obesity management with prices starting from £99.99 a month. Switching medications is a normal and common occurrence — it’s something medical professionals do regularly for conditions like high blood pressure or high cholesterol, whether it’s to reduce side effects or lower costs. We’ll work with you to find the treatment that’s right for your needs, budget and goals.
Should I stay on my current dose if my medication is working?
If your current dose is working and you’re happy with your progress, you can stay on that dose. You start on the lowest dose of weight loss medication, which usually increases every 4 weeks. If you’re experiencing side effects or you’re satisfied with your current weight loss, you can stay on a lower dose. You always have the option to increase your dose when you feel ready.
Will side effects get worse when I increase the dose?
When you increase your dose, side effects can sometimes reappear or worsen. This is simply because your body needs time to adjust to the higher dose. The good news is that these usually improve over time.
Can I use Wegovy while pregnant?
Wegovy should not be used during pregnancy. If you are planning to become pregnant, discontinue Wegovy at least two months in advance.
Do I need to be on contraception with Wegovy?
If you are of childbearing age and sexually active, you should use contraception while taking Wegovy. You can use oral contraceptive pills, non-oral methods such as the implant or IUD, or barrier methods like condoms.
Can GLP-1 medications cause bleeding while on HRT?
Some people taking GLP-1 medications, such as semaglutide (Wegovy) or tirzepatide (Mounjaro), may notice changes in their vaginal bleeding. This can happen more often if they are also using hormone replacement therapy (HRT). Although this is increasingly observed, official guidance is still limited.
These changes might happen because GLP-1 medications slow down digestion. This can affect how your body absorbs hormone treatments — especially HRT taken as tablets, particularly oral progestogens. There don’t appear to be the same issues with hormone patches or intrauterine devices (like the Mirena coil). Weight loss and other body changes may also play a role.
This kind of bleeding is usually not serious, but it’s important to tell your doctor if you experience new, heavy or ongoing bleeding. They can check for other causes and may suggest adjusting your HRT or carrying out further tests if needed.